Soha M.M Eltohamy
Journal of the Egyptian Ophthalmological Society 2021 114(4):110-115
Purpose This study intends to compare the characteristic distributive epithelial pattern by Fourier-domain anterior segment-optical coherence tomography (AS-OCT) corneal mapping between keratoconic and normal eyes. Patients and methods This prospective case–control study included 51 participants who were divided into two groups: study group A (formed of 50 eyes of 26 keratoconic participants) and control group B (50 eyes of 25 healthy controls of matched age and sex with group A). Maps of corneal epithelial statistics within central 5 mm [S: 2–5 mm (superior), I: 2–5 mm (inferior), minimum, maximum, SD (topographic variability), minimum−maximum], and the total corneal pachymetry maps were assessed by the Fourier-domain AS-OCT system and imaged by Scheimpflug imaging corneal topography for both groups. Results For group A of keratoconic corneas, the attained results are as follows: the mean of epithelial thickness at the center was 50.1±7.98 µm, superior 56.01±6.98 µm, inferior 48.73±5.97 µm, minimum 39.95±9.11 µm, maximum 62.92±8.85 µm, minimum−maximum −22.01±10.91 µm, and topographic variability 6.9±4.2 µm. For group B of healthy control eyes, the mean of epithelial thickness at the center was 52.71±3.71 µm, superior 52.29±3.32 µm, inferior 53.42±3.11 µm, minimum 48.89±3.71 µm, maximum 55.92±3.47 µm, minimum−maximum −6.3±3.51 µm, and topographic variability 1.53±0.82 µm. All variables of epithelial thickness between the two groups are significant (P<0.01). In comparing the epithelial map of keratoconus (KCN) with the control group, the epithelium was found to be thicker at the maximum (+7 µm) and superior location (+3.72 µm), but thinner at the minimum (−8.94 µm) and the inferior (−4.69 µm) with highly significant differences in both minimum−maximum (−15.71) and topographic variability (+5.37). Moreover, in KCN, the point of minimum epithelial thickness was in accordance with the minimum point of the total corneal thickness and the maximum point of back elevation. Conclusion The mapping for epithelial thickness utilizing AS-OCT could be a promising tool in KCN diagnosis.
Journal of the Egyptian Ophthalmological Society 2021 114(4):110-115
Purpose This study intends to compare the characteristic distributive epithelial pattern by Fourier-domain anterior segment-optical coherence tomography (AS-OCT) corneal mapping between keratoconic and normal eyes. Patients and methods This prospective case–control study included 51 participants who were divided into two groups: study group A (formed of 50 eyes of 26 keratoconic participants) and control group B (50 eyes of 25 healthy controls of matched age and sex with group A). Maps of corneal epithelial statistics within central 5 mm [S: 2–5 mm (superior), I: 2–5 mm (inferior), minimum, maximum, SD (topographic variability), minimum−maximum], and the total corneal pachymetry maps were assessed by the Fourier-domain AS-OCT system and imaged by Scheimpflug imaging corneal topography for both groups. Results For group A of keratoconic corneas, the attained results are as follows: the mean of epithelial thickness at the center was 50.1±7.98 µm, superior 56.01±6.98 µm, inferior 48.73±5.97 µm, minimum 39.95±9.11 µm, maximum 62.92±8.85 µm, minimum−maximum −22.01±10.91 µm, and topographic variability 6.9±4.2 µm. For group B of healthy control eyes, the mean of epithelial thickness at the center was 52.71±3.71 µm, superior 52.29±3.32 µm, inferior 53.42±3.11 µm, minimum 48.89±3.71 µm, maximum 55.92±3.47 µm, minimum−maximum −6.3±3.51 µm, and topographic variability 1.53±0.82 µm. All variables of epithelial thickness between the two groups are significant (P<0.01). In comparing the epithelial map of keratoconus (KCN) with the control group, the epithelium was found to be thicker at the maximum (+7 µm) and superior location (+3.72 µm), but thinner at the minimum (−8.94 µm) and the inferior (−4.69 µm) with highly significant differences in both minimum−maximum (−15.71) and topographic variability (+5.37). Moreover, in KCN, the point of minimum epithelial thickness was in accordance with the minimum point of the total corneal thickness and the maximum point of back elevation. Conclusion The mapping for epithelial thickness utilizing AS-OCT could be a promising tool in KCN diagnosis.